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New Parvo Treatment Protocol

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4.5K views 2 replies 2 participants last post by  vet@veterinaryinsight.com  
#1 ·
Recently Colorado State University developed a new outpatient treatment protocol for Parvovirus enteritis: http://csu-cvmbs.colostate.edu/documents/parvo-outpatient-protocol-faq-companion-animal-studies.pdf

In their studies, the survival rate was comparable to what could be achieved with aggressive in-hospital treatment. (80% survival for this protocol vs. 90% for in-hospital treatment.)
Certainly many people have attempted "at home" Parvo treatment in the past, but the success rate for this sort of limited care has been poor. This new treatment protocol takes advantage of two newer drugs (Cefovicin--AKA Convenia--as an antibiotic and Maropitant--AKA Cerenia--as an antivomiting treatment).

A couple of notes about this protocol:
1) I still strongly advocate for in-hospital treatment, owing to the amount of monitoring that can be performed. (e.g. Our in-hospital protocol calls for daily electrolytes, twice daily glucose levels, daily white blood cell counts, twice daily body weights, etc.). That sort of aggressive monitoring is difficult to achieve on an outpatient basis.
2) If you read this protocol carefully you will note that it calls for an extreme amount of owner involvement and follow-up. This is not a protocol for someone who isn't going to be returning to the hospital every day, and who isn't very tuned in to their dog.
3) I personally believe even a 90% survival rate to be low, and 80% to be unacceptably low. But, for owners who cannot afford to hospitalize their pet, this may be a good alternative.
4) I haven't priced what this protocol might cost for a client, but it still wouldn't be cheap. Both the Convenia and Cerenia are expensive medications. With recheck exams, repeated injections, the A/D diet, recheck bloodwork, and the fluids/IV lines/needles, I would guess that this would run 50% of the cost of in-hospital treatment.
5) And finally, (tongue in cheek), "don't try this at home..." This protocol is intended to be carried out with significant involvement from your veterinarian. Some non-veterinarians can doubtless purchase all of the supplies for this protocol and may attempt to perform Parvo treatment on their own. The mainstay of Parvo treatment is fluid therapy, which is a delicate art. It requires the ability to assess dehydration accurately and to take into account ongoing needs, ongoing losses, current level of dehydration, electrolyte needs, glucose needs, etc. In other words, someone with medical training needs to be running the show.

I hope that you all find this as interesting as I did!
 
#2 ·
Recently, Animal Planet published a medical blog on how to treat parvo at home following this same protocol, minus the specifics on daily mineral level testing. Animal Planet was slammed by the AVMA, thousands of vets, vet techs and pet owners for posting that article. The article was removed from their website fairly quickly. The fear was that owners would not accept the standard of care if there were a cheaper option and the standard of care would be challenged continuously going forward, resulting in a lower survival rate.

The article you provided suggested 80% survival, but it doesn't go into the specifics of how the study was conducted. It also mentioned it was presented June, but hasn't undergone a peer review. Do you know the status of that review?
 
#3 · (Edited)
I disagree with the AVMA's stand on this issue. I don't think that providing owners with information on treatment options and expected outcomes diminishes their ability to make an informed decision. Certainly some people may choose to pursue a less expensive option, but that is their choice based upon the available information. To not provide owners with this information is akin to saying, "I don't trust you to make a good decision, so I will only give you information so that you can choose what I think is right." Interestingly Colorado State University has published the protocol on the web and recently had an extended question and answer section on their Facebook account to disseminate the information on this protocol (thousands of individuals, both from the general public and the veterinary community participated).
As far as I know, the study itself has not yet been released. It was presented as an oral abstract in June at the national Internal Medicine conference (ACVIM conference). (An "abstract" is a brief synopsis, often followed by a question and answer period, at a conference. They are used to sharpen a study and to get feedback as to whether the original study should be broadened, repeated, or modified, prior to seeking publication. This is a form of peer review, although the term "peer review" is used more commonly to describe publication in a peer-reviewed medial journal.) CSU has indicated that this study will eventually be published in one of the veterinary journals (most of which are peer reviewed), but to my knowledge this has not yet taken place. It is not at all unusual for a study to take 1-2 years to go from completion to publication.