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Discussion Starter #1
It seems all of them have drugs MDr1 dogs are not good with. Our dog is mutant/non-mutant. What do you use?
 

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This is a discussion you should have with your vet since he/she will have to deal with any side effects
 

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Discussion Starter #3
The vet didn't know much about mdr1 so it's up to me to do research... All heartworm meds have sensitivity. I just wonder what other rough collie owners use? It's between Revolution and Interceptor now for me.
 

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At the doses used for heartworm prevention, any one of them should be safe especially for a non-mutant/mutant. Personally I don't trust topical heartworm medications like Revolution.
 

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I would discuss it with your vet - although (and I am NOT a vet) I believe most oral heartworm medications are safe for MDR1 breeds - as I discussed this with my previous vet (before we moved) and he said she would be fine on heartworm meds (this is when her status was unknown).
 

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Discussion Starter #7
Here is the list of known problem drugs from the WSU website: http://www.vetmed.wsu.edu/depts-VCPL/drugs.aspx

Ivermectin, selamectin, milbemycin, and moxidectin are the relevant drugs for heartworm prevention.
Yeah all the meds are on the list! But I talked to the breeder. Mom-dog (dame) is a mutant/mutant but did great with Interceptor, so we will purchase that brand. She says now as an adult they use shots, but I have no idea what shots there are against heartworm (must be sort of like a 3 months medicine shot or so).
 

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Yes. dogs were having reactions to it. Took it off the market and and did some tweaking. Ran test/studies galore and now it is back.
 
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