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Angel Eyes almost always works because it treats the cause of the reddish-brown staining, usually a red yeast. The active ingredient in Angel Eyes is Tylosin (antibiotic) and you can buy straight Tylosin at farm / ranch supply stores as it is also used for respiratory infections in chickens.

Also, it is also seemingly impossible for some dogs to keep the stains away once you stop giving the med. Small breeds, especially those with "smooshed" faces have really tiny tear ducts. They tend to clog up easily or just not drain properly in the first place, so the excess tears ends up in the fur under the eyes...a perfect breeding ground for yeast...and so the cycle goes.

I have used Tylosin successfully in our dogs. And once I stopped the stains returned. Since I don't want to keep them on constant antibiotics I choose to live with a bit of staining that seems to plague one dog. For her I wipe around the eyes 2-3 times per day whenever I think about it) with either regular water or saline eye drops (buy the store brand at walmart) on a good sturdy wash cloth. Then I make sure that those cloths get thrown in with our bath towels so they get bleached before being reused. It's important to do the wiping regularly so the dried debris doesn't build up. If it does I just soak a wash cloth with warm water and keep wiping until it loosens up and I can remove it. Then, for maintenance, be sure to clean around the eye well and then gently massage the inner corner of the eyes where the tear ducts are located. Clean up any "stuff" that has run down under the eye. If you do that at least daily it keeps things down to a reasonable level.

However, if I had a completely white dog that had lots of staining on the eyes as well as around the mouth I would definitely use a product (like Angel Eyes or Tylosin) to get it under control.
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