Your best option would probably be to board him while you are gone. That way, he's taken care of, and you can concentrate on your wife.
If you do take him with, tho NOT leave him loose in the motel room. Keep him crated while you are gone, leave the TV or radio on, and and put our the Do Not Disturb sign. The last thing you will want to deal with is a dog who has slipped past the housekeeper and is now running loose in a strange place, or one who has barked at every little noise and has motel staff and guests fuming, or has panicked at being left alone in a strange place and has destroyed the room and/or injured themselves.
If you do take him with, tho NOT leave him loose in the motel room. Keep him crated while you are gone, leave the TV or radio on, and and put our the Do Not Disturb sign. The last thing you will want to deal with is a dog who has slipped past the housekeeper and is now running loose in a strange place, or one who has barked at every little noise and has motel staff and guests fuming, or has panicked at being left alone in a strange place and has destroyed the room and/or injured themselves.