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It's an infection and/or infestation now. You'll need to take him to the vet for prescription meds before it gets even worse. It's beyond home remedies. They are likely to put him on oral antibiotics and/or antifungal meds in addition to topical treatment.

It may have started out as a food or environmental allergy - to prevent future outbreaks you might look at changing his diet and/or being more careful about what he's coming in contact with. Talk to the vet about it when you being him in to have the wounds treated.
 
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