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It sounds like separation anxiety - specifically with your wife. Kane used to act that way with my husband. If we were all together everything was great, but if my husband would leave the house Kane would get really upset, pacing around, whining, looking terrified. If my husband left the house and took our other dog Pepper with him it was like the end of the world for Kane. We've been working on it though and he's improved a lot.
 
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