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Also ... I love revolution! Not only can I skip the Frontline Plus ... but also skip the Heartguard Plus ... and it is not a huge amount of liquid on their skin to get all over everything. It may be a bit more expensive ... but works very well ... at least for Abbylynn. Next season I am switching the other two dogs to the same. :)
 

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I believe the effectiveness of the product(s) wears off in a month. Maybe a call to the vet or someone else on here knows for sure about the bloodstream question?
 
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