not a vet when I was dealing with chronic conditions *yeasty ears) it was an autoimmune response.. So that would be an area to search, find facebook groups or forum groups. in general bacteria lives on all of us and our natural immune system protects us from it. When I was looking for food.. I had to find a protein that they had never been exposed to before.... Chicken and beef, grain, dairy, eggs, chicken fat were triggers for them. simple limited ingredients were helpful to see any results if it was helping was about 60 days.. it was a quick response if they ate something that was not right for them.. their ear lining would turn read and have a bad episode of the ears and that took time to run it's course and be on the mend. Nothing is instant. and even in healing, they would still have episoides but they were milder, and shorter and further apart to know I was on the right track Trying to think of a tittle of a specialty vet that you could talk to. And if you have a vet college in your state you could send your medical records to them and get advice of any test they would want to see and your vet could do the test if you can't travel to them. I know how frustrating it can be... first is to try to find out what aggravates the situation and stop the aggravation so the body can rest , restore and try to heal its self. The other is the predisone approach which shuts the body down completely immune wise, gives the body a chance to stop reacting, rest recover.. get rid of the inflamation in the body from the reactions, in hopes that when your dog is weaned off the predisone the body will have reset to normal function... that is something to talk to a vet that deals with auto immune situations as you must monitor your dogs organs on predisone because it can damage them.. Find the right vets to work with. Hugs...