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Thankfully, even genetic behavior can often be improved and modified with the appropriate training plan, especially when you start early! Resource guarding specifically often has a quite good outcome. You've got good instincts with encouraging your kids to give the dog space, and a crate or pen where the dog can safely enjoy his goodies without being bothered is absolutely a great management tool to start with.

I would also highly suggest the booklet Mine! by Jean Donaldson - available relatively cheaply as an e-book if you want it instantly. Dr. Patricia McConnell, an applied animal behaviorist who works with difficult dogs and also writes many helpful books and articles about it, has a blog post here that will give you a brief overview of how trading games work, step by step, to modify the dog's reactions from "people might take my goodies" to "people being around my goodies is awesome". You can do the treat-tossing with the kids in the room, or (if they're old enough, interested, and happy to follow instructions), the kids can help tossing treats themselves. You can even have the dog behind a gate or pen at first for an added level of security, both for the dog and for you.

Kids move oddly, speak in higher pitches, and are generally more unpredictable than adults, so it's not uncommon for dogs to be a little more wary around them, even if they grew up with kids around. But with some work, it's very likely you can help him feel more secure. It's a good idea to always let him have his space with his food and high-value chews or treats, of course, and he may never be a dog who will be happy with kids being on top of him (figuratively) while he has an awesome goody. But that doesn't mean there's no room for improvement so you can all feel a little more secure and comfortable with the situation.
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