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As far as I'm aware, terms like 'red nose' and 'bully' have different meanings to different people. I've often seen 'red nose' to mean any red dog that looks roughly like an American Pit Bull Terrier or American Staffordshire Terrier, but neither of those are large dogs by any means. American Bully is establishing itself as a breed, but even the Pocket size variation is a pretty stocky dog, even if they tend to be shorter than your average APBT/AmStaff. Are these the breeds you mean?
With any breeding project, it's extremely important to follow ethical breeding practices. Both dogs should be thoroughly screened for genetic and structural health issues, including things like hip and elbow x-rays, heart and eye evaluations, and DNA screening for heritable issues. Only dogs who are healthy, in good condition, and have minimal risk of passing heritable health problems onto their pups should be bred, and even then they should be fully physically mature (2 for most breeds, maybe a little older for giant breeds). Additionally, both dogs should be screened for brucellosis, which is a canine STD.
Temperament also needs to be considered, as many behavior problems have strong genetic tendencies - for example, a dog with an anxious mother is more likely to be anxious, even if they're hand-reared from birth and never see her. In the best case scenario, you also have information about health and temperament from your breeding dogs' parents, grandparents, sibling, aunts, uncles, etc. The bigger picture you have of the pedigrees, the better.
Dogs with extremely different physical structure - including vastly different sizes - can cause problems, because genetics can combine in unexpected ways that make the puppies structurally unsound and prone to things like joint issues. If the bitch is the smaller dog, even the act of mating could injure her. It's usually far safer to mix breeds that are more structurally similar.
It's also the breeder's responsibility to expose the pups to as many different sounds, sensations, and experiences as possible without overwhelming them. They should go home already familiar with living in a household - different kinds of flooring, appliances like a vacuum or blender, different kinds and ages of people (ideally also medical equipment like wheelchairs, canes, etc.), being comfortable with being touched all over - including feet, ears, mouth, tail - so they will be less stressed by things like nail trims and vet exams in the future.
Additionally, have a healthy amount of savings set aside in case complications arise. Dogs with large, blocky heads like many bully breeds are more likely to need surgical intervention at birth, and even then there's a lot that can go wrong. If you don't have funds or easy access to a local vet who can handle out-of-hours emergencies, you risk losing puppies and even mom if there's pre- or post-birth complications.