Pill pockets, cheese, yogurt, peanut butter, anything that's not normally in his bowl. I also place my cats - dogs are all too large - in my lap with head facing away from me, when I am trying to give them pills. This keeps them from being able to back away. I also try to give them a treat after the medicine process so that it's not something totally unpleasant for them. Good luck finding what works for you.