This product is NOT safe and should be withdrawn from the market. We almost lost a 5 yr. old rat terrier last week because the vet suggested switching from Frontline Plus to Advantix. The dog got sick almost immediately...couldn't breathe, vomiting, couldn't walk, etc.
We spoke to Bayer, whose vet opened mouth and inserted foot by saying "it could not have possibly gotten into his bloodstream". Yes, those are the symptoms of it getting into his bloodstream.
We believe he was poisoned by OP (organophosphates) and since 43% of the ingredients are listed as "other" we can't even know the all the ingredients. And what makes the matter much, much worse is this stuff does NOT wash out like all previous types of flea and tick meds. Even the vet did not know this...she said just give him a bath it will be gone.
People need to be aware of these dangers. Bayer is certainly not going to tell you, so we are. After bathing him twice in Dawn dish detergent, as prescribed by a Bayer Animal health consultant, he is still having problems with urgent, frequent urination. We are highly concerned about liver and kidney damage at this point.
If any one else has had a problem with this product, please contact me, since I will be filing a complaint with the FDA.
Also, I will update this tomorrow following his second vet visit.