Does anyone have any experience with MDR 1 testing for their aussie or other affected breed? We are going to have our new puppy tested because a friend had an aussie that had the mutation (genetic) and has nothing but horror stories to tell related to the veterinary care of his dog. Here is a quote from Washington State University's website that offers testing:
Multidrug Sensitivity in Dogs
Some dog breeds are more sensitive to certain drugs than other breeds. Collies and related breeds, for instance, can have adverse reactions to drugs such as ivermectin and loperamide (Imodium). At Washington State University's College of Veterinary Medicine you can get your dog tested for drug sensitivity and keep up with the latest research.
Drug sensitivities result from a mutation in the multi-drug resistance gene (MDR1). This gene encodes a protein, P-glycoprotein that is responsible for pumping many drugs and other toxins out of the brain. Dogs with the mutant gene cannot pump some drugs out of the brain as a normal dog would, which may result in abnormal neurologic signs. The result may be an illness requiring an extended hospital stay - or even death.
Most Commonly Affected Breeds
Australian Shepherd (Mini)
I am very interested to hear your thoughts. Thanks