Aussies and MDR 1???
DogForums.com is the premier dog Forum on the internet. Registered Users do not see the above ads.
+ Reply to Thread
Results 1 to 15 of 15

Thread: Aussies and MDR 1???

  1. #1
    Junior Member brifox's Avatar
    Join Date
    Jan 2010
    Location
    Alameda
    Posts
    22

    Aussies and MDR 1???

    Hi,

    Does anyone have any experience with MDR 1 testing for their aussie or other affected breed? We are going to have our new puppy tested because a friend had an aussie that had the mutation (genetic) and has nothing but horror stories to tell related to the veterinary care of his dog. Here is a quote from Washington State University's website that offers testing:

    Multidrug Sensitivity in Dogs

    Some dog breeds are more sensitive to certain drugs than other breeds. Collies and related breeds, for instance, can have adverse reactions to drugs such as ivermectin and loperamide (Imodium). At Washington State University's College of Veterinary Medicine you can get your dog tested for drug sensitivity and keep up with the latest research.

    Drug sensitivities result from a mutation in the multi-drug resistance gene (MDR1). This gene encodes a protein, P-glycoprotein that is responsible for pumping many drugs and other toxins out of the brain. Dogs with the mutant gene cannot pump some drugs out of the brain as a normal dog would, which may result in abnormal neurologic signs. The result may be an illness requiring an extended hospital stay - or even death.

    Most Commonly Affected Breeds
    Australian Shepherd
    Australian Shepherd (Mini)
    Collie
    Long-haired Whippet
    McNab
    Silken Windhound


    I am very interested to hear your thoughts. Thanks

    Brian.

  2. Remove Advertisements
    DogForums.com
    Advertisements
     

  3. #2
    Senior Member Keechak's Avatar
    Join Date
    Aug 2008
    Location
    Wisconsin USA
    Posts
    8,591

    Re: Aussies and MDR 1???

    I will be getting Hawkeye tested when I can afford it. Untill then I am just keeping him away from all drugs, his sire was tested and shown as N/M (carrier). I know the test costs about $70 and you have to have a vet take a blood sample and then send it to the testing place. I also recommend you keep your puppy away from all drugs including flea and tick medication untill you get him tested.

  4. #3
    Junior Member brifox's Avatar
    Join Date
    Jan 2010
    Location
    Alameda
    Posts
    22

    Re: Aussies and MDR 1???

    Quote Originally Posted by Keechak View Post
    I will be getting Hawkeye tested when I can afford it. Untill then I am just keeping him away from all drugs, his sire was tested and shown as N/M (carrier). I know the test costs about $70 and you have to have a vet take a blood sample and then send it to the testing place. I also recommend you keep your puppy away from all drugs including flea and tick medication untill you get him tested.
    Thanks Keechak. I was actually debating whether to post this or just e-mail you directly. I just got the test kit in the mail, it is $70 but you have an option to take two cheek swabs instead of a blood sample at the vet. The cheek swabs can lower the cost quite a bit I think.

  5. #4
    Senior Member luv2byte's Avatar
    Join Date
    Oct 2009
    Location
    Washington State
    Posts
    1,526

    Re: Aussies and MDR 1???

    We had Skyler tested after he was home with us approx 72hrs. The results were emailed to us exactly when promised. I am lucky enough to have a vet that is an old student of the vet that found this gene. My vet worked with Dr Mealey to create a safe plan of care for Skyler's neutering & monthly flea/heart worming meds. I also emailed WSU with some of my own questions about the results, Dr Mealey answered so quickly & with throughough answers. Skyler tested mutant/normal so our vet & us decided to treat as though he would react to meds & not take a chance.

    Skyler was neutered a week ago today, he woke up without being nauseaous, drugged, or any side effects. He was happy & perky when he woke up. Our vet also used the protocol a couple months ago for a spay, same results. No major pain symptoms, no nausea, drugged. He bounced out to us happy as ever & never acted as if he even had a procedure. Our vet was so impressed that she said she is changing the standard protocol for all spay/neuters & also might help avoid post op issues at the same time.

    Dr Mealey recommended Frontline Plus & Heartguard to our vet. It is my understanding that so far ONLY these two products have been throughoughly tested on dogs with the MDR1 gene. It was also stressed that it is brand name only at this point.

    Hope that helps.
    Ellie R. (married w pets)
    <img src=http://i33.photobucket.com/albums/d67/lv2byte/Christmas2010-2.jpg border=0 alt= />

  6. #5
    Senior Member Keechak's Avatar
    Join Date
    Aug 2008
    Location
    Wisconsin USA
    Posts
    8,591

    Re: Aussies and MDR 1???

    It's pretty sad a good friend of mine who has a 1 year old show potential just had an MDR1 issue. He noticed his pup shaking slightly and tilting his head they rushed him to the vet and found he was a carrier of MDR1. My friends FiancÚ had given the puppy two medications just days before, one for fleas and one for ticks. The puppy now has permanent brain damage which has resulted in heightened aggression with other dogs, I am unsure if they are still going to show him or not.

    It seems that MDR1 carriers are also affected but not as serious as MDR1 "affected" M/M dogs.
    Last edited by Keechak; 02-16-2010 at 10:55 PM.

  7. #6
    Senior Member Keechak's Avatar
    Join Date
    Aug 2008
    Location
    Wisconsin USA
    Posts
    8,591

    Re: Aussies and MDR 1???

    dosen't heartguard have Ivermectin in it?

  8. #7
    Senior Member luv2byte's Avatar
    Join Date
    Oct 2009
    Location
    Washington State
    Posts
    1,526

    Re: Aussies and MDR 1???

    Quote Originally Posted by Keechak View Post
    It's pretty sad a good friend of mine who has a 1 year old show potential just had an MDR1 issue. He noticed his pup shaking slightly and tilting his head they rushed him to the vet and found he was a carrier of MDR1. My friends Fiance had given the puppy two medications just days before, one for fleas and one for ticks. The puppy now has permanent brain damage which has resulted in hightened agression with other dogs, I am unsure if they are still going to show him or not.

    It seems that MDR1 carriers are also affected but not as serious as MDR1 "affected" M/M dogs.
    OMG! That is so sad! I hope as the pup gets older it heals more.

    It scared me so much when I read about it that I talked to our vet before we brought him home, I got lucky & stumbled upon the info when trying to learn more about Skyler's breed before he came home. The breeder gave virtually NO education about this gene mutation.
    Ellie R. (married w pets)
    <img src=http://i33.photobucket.com/albums/d67/lv2byte/Christmas2010-2.jpg border=0 alt= />

  9. #8
    Senior Member luv2byte's Avatar
    Join Date
    Oct 2009
    Location
    Washington State
    Posts
    1,526

    Re: Aussies and MDR 1???

    Quote Originally Posted by Keechak View Post
    dosen't heartguard have Ivermectin in it?
    Yes. Dr Mealey, WSU vet, explained to my vet that this one brand has been tested on all mutation forms thoroughly and it was found safe. I asked our vet about it because I was terrified to give it to him, she said she also questioned it but it is only recommended because of the testing that has been done.
    Ellie R. (married w pets)
    <img src=http://i33.photobucket.com/albums/d67/lv2byte/Christmas2010-2.jpg border=0 alt= />

  10. #9
    Senior Member Keechak's Avatar
    Join Date
    Aug 2008
    Location
    Wisconsin USA
    Posts
    8,591

    Re: Aussies and MDR 1???

    Quote Originally Posted by luv2byte View Post
    OMG! That is so sad! I hope as the pup gets older it heals more.

    It scared me so much when I read about it that I talked to our vet before we brought him home, I got lucky & stumbled upon the info when trying to learn more about Skyler's breed before he came home. The breeder gave virtually NO education about this gene mutation.
    In our contract our breeder had us agree to ether test him for MDR1 or avoid all drugs associated with being bad for MDR1 affected dogs.
    Which is fine by me thats what we would have done anyways

  11. #10
    Senior Member Keechak's Avatar
    Join Date
    Aug 2008
    Location
    Wisconsin USA
    Posts
    8,591

    Re: Aussies and MDR 1???

    Quote Originally Posted by luv2byte View Post
    Yes. Dr Mealey, WSU vet, explained to my vet that this one brand has been tested on all mutation forms thoroughly and it was found safe. I asked our vet about it because I was terrified to give it to him, she said she also questioned it but it is only recommended because of the testing that has been done.
    that is really weird, simply because Ivermectin was the first drug found to be dangerous to MDR1 dogs. I am not calling them liars at all I just need to see the study to truly feel safe myself.

  12. #11
    Senior Member luv2byte's Avatar
    Join Date
    Oct 2009
    Location
    Washington State
    Posts
    1,526

    Re: Aussies and MDR 1???

    After learning more about the gene after Skyler's test results were back I emailed the importance of the education to our breeder & sent her the website. She emailed me a couple days later and said she is now going to give more info to adoptive families - no idea if she really is, I would hope so. I got lucky & learned about it only because I am so anal & detailed about researching anything new, including pet breeds.

    I totally understand, I would feel the same way. It is in the literature on the website that the standard flea med dosing of ivermectin is safe, it doesn't single out those that are mutant/mutant. Our vet called Dr Mealey directly, then again, as I mentioned it is her old professor so I got lucky I think. We've been giving Skyler his monthly dose of Frontline plus & Heartguard without any issues....so far...and hope to never have any.

    I think everyone with the various breeds that this affects should test as soon as possible. There is a list of 6-8 breeds, if I remember correctly, that are affected.
    Ellie R. (married w pets)
    <img src=http://i33.photobucket.com/albums/d67/lv2byte/Christmas2010-2.jpg border=0 alt= />

  13. #12
    Junior Member brifox's Avatar
    Join Date
    Jan 2010
    Location
    Alameda
    Posts
    22

    Re: Aussies and MDR 1???

    Quote Originally Posted by Keechak View Post
    In our contract our breeder had us agree to ether test him for MDR1 or avoid all drugs associated with being bad for MDR1 affected dogs.
    Which is fine by me thats what we would have done anyways
    I wonder if your breeder is the rule or the exception? Ours didnt mention it at all, found out about it because of someone we met (the friend) at my wife's parents boat dock. Then I googled it. I am certainly going to mention it to the breeder and suggest she add it to her contract.

  14. #13
    Senior Member luv2byte's Avatar
    Join Date
    Oct 2009
    Location
    Washington State
    Posts
    1,526

    Re: Aussies and MDR 1???

    I think Keechak's experience is an exception to the rule, a very good exception. I wish all breeders were as considerate & passionate about education of the gene.
    Ellie R. (married w pets)
    <img src=http://i33.photobucket.com/albums/d67/lv2byte/Christmas2010-2.jpg border=0 alt= />

  15. #14
    Senior Member agility collie mom's Avatar
    Join Date
    Jan 2008
    Location
    PA
    Posts
    1,963

    Re: Aussies and MDR 1???

    Quote Originally Posted by luv2byte View Post
    We had Skyler tested after he was home with us approx 72hrs. The results were emailed to us exactly when promised. I am lucky enough to have a vet that is an old student of the vet that found this gene. My vet worked with Dr Mealey to create a safe plan of care for Skyler's neutering & monthly flea/heart worming meds. I also emailed WSU with some of my own questions about the results, Dr Mealey answered so quickly & with throughough answers. Skyler tested mutant/normal so our vet & us decided to treat as though he would react to meds & not take a chance.

    Skyler was neutered a week ago today, he woke up without being nauseaous, drugged, or any side effects. He was happy & perky when he woke up. Our vet also used the protocol a couple months ago for a spay, same results. No major pain symptoms, no nausea, drugged. He bounced out to us happy as ever & never acted as if he even had a procedure. Our vet was so impressed that she said she is changing the standard protocol for all spay/neuters & also might help avoid post op issues at the same time.

    Dr Mealey recommended Frontline Plus & Heartguard to our vet. It is my understanding that so far ONLY these two products have been throughoughly tested on dogs with the MDR1 gene. It was also stressed that it is brand name only at this point.

    Hope that helps.
    I have always used Interceptor and have avoided Heartguard in my collies.
    Are you sure that you didn't misunderstand the heartworm recommondations?
    Here is a link from the WSU site listing the drugs that are harmful to dogs that test positive for the MDR1 gene. Ivermectin is the drug that is used in Heartguard.
    http://www.vetmed.wsu.edu/depts-VCPL/drugs.aspx
    "Dogs are our link to paradise. They don't know evil or jealousy or discontent. To sit with a dog on a hillside on a glorious afternoon is to be back in Eden, where doing nothing was not boring--it was peace." - Milan Kundera

  16. #15
    Senior Member luv2byte's Avatar
    Join Date
    Oct 2009
    Location
    Washington State
    Posts
    1,526

    Re: Aussies and MDR 1???

    My vet talked to WSU directly, they were very specific about brand due to extensive testing that was done. Please do as your vet says & within your own comfort level. I am doing as my vet says based on her consultation with WSU.

    As for ivermectin, read on WSU's site under the FAQ about ivermectin. It states afffectes are when in large doses.
    Ellie R. (married w pets)
    <img src=http://i33.photobucket.com/albums/d67/lv2byte/Christmas2010-2.jpg border=0 alt= />

  17. Remove Advertisements
    DogForums.com
    Advertisements
     

+ Reply to Thread

Quick Reply Quick Reply

  • Decrease Size
    Increase Size
  • Remove Text Formatting
  • Insert Link Insert Image Insert Video
  • Wrap [QUOTE] tags around selected text

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
SEO by vBSEO 3.5.2 ©2010, Crawlability, Inc.