Antibiotic - Zeniquin 100mg
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Thread: Antibiotic - Zeniquin 100mg

  1. #1
    Junior Member mhowd's Avatar
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    Unhappy Antibiotic - Zeniquin 100mg

    My dog, a 9 year old yellow lab named Chelsea was recently diagnosed with a urinary tract infection and kidney infection. My vet put her on an antibiotic called Zeniquin. She told me that this was a very strong antibiotic and she prescribed 1 tablet per day for 20 days. The tablets are 100mg.

    I started Chelsea on the medication and after only 1 day she stopped eating for the most part. She would take a couple of mouth fulls and that was it. I've tried feeding her various things to get her to eat. I tried hamburger/rice, canned dog food (which she normally eats dry), I tried steak, veal, chicken all mixed with rice. Scrambled eggs, milk toast, etc.. What she was able to eat, she would vomit up.

    I went back to the vet when I came home and she developed an eye infection. This was about 10 days after being on the Zeniquin medication. They gave me eye ointment and that cleared her eyes up within a matter of days. While I was at the vets, I told them that Chelsea was not eating and the little amounts that she did eat, she vomited up. I was told the antibiotic would upset their stomach - but since I had an appointment scheduled for December 2, they told me to keep trying various diets to get her to eat. The vet felt around her neck and back end, and told me that Chelsea's lymph nodes were swollen and we should keep an eye on that.

    I've since stopped giving her the medication. As you can imagine, she's lost a lot of weight. She is still not eating - I called the vet up yesterday, and have rescheduled my appointment for Monday - I just don't think it a good idea to wait an entire week to go back to the vet.

    Has any one heard of this medication? Does anyone have any suggestion of what I can try to feed Chelsea in the meantime? She's always been a very good eater, never picky - and loves her milk bones. Now, she's very lethargic (probably due to not eating), she turns her nose up at everything I try to feed her.

    I know I have an appointment on Monday, but I'm just trying to get some ideas of what is happening to her.

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  3. #2
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    I'm not sure why they would tell you to continue to give that antibiotic when it is obvious she isn't handling it well. Usually the vet will switch to another antibiotic if the dog is intolerant to one. There are certainly others out there to try. My dog had a bladder infection, and did the same thing on Baytril. We immediately stopped it and she was better in a couple days and then we switched to another antibiotic that she did just fine with.

    The enlarged lymph nodes could possibly be from the kidney infection I guess, but you could also have something worse going on at the same time, like (I hate to say this) Lymphoma. Lymphoma can affect their appetite too. How long has this been going on? It kind of sounds like it has been awhile. If it has been more than a few days off the Zeniquin, and she is still having these symptoms of not wanting to eat and vomiting, you have to look for other causes to this. A nasty kidney infection can cause kidney failure and that would cause those symptoms too.

    A blood panel to assess her kidneys, liver, etc. is probably a good idea as well as a culture of the urine, if it hasn't already been done, to find out exactly which antibiotic will be the best for fighting this infection.

    If she has not been eating and has been vomiting for a long time, she is probably severly dehydrated, and needs at least subcutaneous if not IV fluids given.
    Last edited by Dogged; 11-25-2006 at 09:02 PM.

  4. #3
    Junior Member mhowd's Avatar
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    Thanks - she's been off the Zeniquin since Monday so it's been over 5 days now. I went against the vets advice and decided to take her off the medication. I'm not sure if the urine was cultured - I do know that when I took her in the vets office initially, they did a urinalysis and drew blood. The urinalysis came back positive for an UTI and Kidney infection. I called back a day or so afterwards to find out the results of the blood work, and they told me that everything looked great. They even told me that the kidney infection wasn't as bad as they originally thought.

    The veterinary office I use is very reputable. The only thing that does bother me, is the fact that I normally see a vet, who actually did hip surgery on Chelsea a few years back - he's a great vet and I really like him. He explains everything in a way that is very understandable. However - during this recent episode, I wasn't able to get an appointment with him, Chelsea has been seen by two other vets in the office. I called up yesterday to make an appointment with him, but due to the holiday, he isn't in until Monday. I made the appointment for Monday morning at 10am. However, I still can't get her to eat.

    I was afraid of Lymphoma - but could that happen so quickly? If it is Lymphoma, do you know what course of treatment is available? Do you have any ideas of what to try to feed her in the meantime?

    I really appreciate your responses. As you can probably tell, I'm very attached to my dog and it hurts so much to see her going through this - I just wish she would eat something.

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    Lymphoma can happen at anytime, and very quickly. The treatment would be chemotherapy or if you decided against that, then there really is no other treatment beside putting them on Prednisone as a last ditch effort to keep it at bay for a short time. It doesn't usually work for long though.

    So, she hasn't been eating for a week? That is bad. What about drinking? has she kept anything down? She really needs to get to a vet right away and be re-assessed and given some IV fluids, or you run the risk of her other organs shutting down, plus the fact that dehydration isn't pleasant. I don't think this should wait until Monday. Do you have an emergency vet in your area?

    I think she is past the point of just finding the right food for her to eat. I don't think that you will just find the right food, and that will solve your problem, but that being said, I will tell you that when my old kidney failure dogs would eat nothing else, they would still sometimes eat El Pollo Loco chicken (white meat, no skin).

    But if she is vomiting everything she eats, that will just make her even more dehydrated.
    Last edited by Dogged; 11-25-2006 at 09:44 PM.

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    Junior Member mhowd's Avatar
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    She's eaten very little, and what she has eaten, she's vomited up. She's been drinking water and I've been feeding her ice cubes - now, when she vomits, it's more yellowish liquid than anything solid - I guess that's bile? The past day, even ice cubes aren't interesting to her. How can you tell if she's dehydrated? Are there any signs for me to look for?

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    Junior Member mhowd's Avatar
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    Hi Dogged - I just called the emergency vet and they agree with you - she really needs to be on IV liquids. I'm taking Chelsea now to the emergency vets - just wanted to let you know.

    Thanks again for all your help -

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    To determine hydration, you gently pull on the skin to see if it will snap back like elastic. If the elasticity isn't there, then I would be very concerned a dog has become dehydrated. I think you can probably check the gums for a nice pink color, too.

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    Please keep us posted!

  10. #9
    Junior Member mhowd's Avatar
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    I got back from the emergency vets and she was slightly dehydrated. They decided to run some blood tests to check to see what's happening. They also suggested I keep her there overnight to get some fluids pumped into her. The blood test came back and seems the lymphites (spelling?) levels were over 7 times the norm. Her liver is swollen as well. All indications point to Lymphoma. The ER vet suggests I take Chelsea to her regular vet Monday morning as planned and have one of the lymph nodes biopsied to determine the exact type of cancer. She told me that some types of cancer can be treated with chemo and dogs can generally handle the treatment well - thereby giving me some more time with her (1-3 years possibly). Other types of cancer (if it gets into the bones) are not treatable and I would therefore be faced with putting her down.

    I appreciate everyone's help - I just can't believe this has happened so quickly. Breaks my heart.

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    Poor baby. If her liver is big, she could have a mass there too if that is what is happening. A ultrasound of the abdomen might be indicated to see what is happening there. If she has a liver mass, that will probably change your treatment possibilities. I'm not sure which test would be recommended to do first, but I think I would want to find out about the liver first.

    Good luck.

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    Junior Member mhowd's Avatar
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    Thanks - I'll ask the vet tomorrow morning about the liver. I gave her a small portion of boiled chicken/rice as recommended by the ER vet (about 1 cup) and she ate very little, not even 1/4 cup. She does want to drink water, but I was told to only give her small portions of that as well. I still can't believe this is happening.

    Thanks for everyone's insight on this. Tomorrow morning I'll should know more.

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    Yes, small amounts of water often is a good idea, as long as she is keeping it down. Same with food. If she is vomiting though, you don't want to give her anything because that will dehydrate her further. Did the ER vet give any drugs to settle her stomach?

    Beechnut or Gerber chicken baby food is good to give them. They usually like it and it is easy on the tummy. Just the plain chicken though, not chicken/rice or chicken/noodles.

    Do you have El Pollo Loco in your area, because that has really worked for me before (no skin though).

    There is a food at the vet called Hills A/D which is a recovery type canned food that some really like too.

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    Junior Member mhowd's Avatar
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    Thanks Dogged - I took her to vet this morning. We're going to have an ultrasound tomorrow morning. Chelsea did loose her vision last night. The vet checked her eyes and confirmed that she is now blind - although he is not sure if it is permanent. After the ultrasound, I suppose we will know better if a biopsy is in order. He explained to me that if the ultrasound shows a lot of cancer, then there won't be a need for a biopsy.

    The ER vet did give her medication to reduce the acid in her stomach, but she is still eating very little. Last night I was able to get maybe 1/2 chicken breast in her and she didn't vomit. Not sure if we have El Pollo Loco in this area - I'm in South Central Pennsylvania and never heard of it before.

    Chelsea is also starting to go jaundice - I guess from the inflamed liver. My vet today also told me that her spleen was slightly enlarged.

    All of this, just doesn't sound good and I'm afraid I will be faced with a very difficult decision tomorrow. I don't have kids, so she is my child. I just can't believe this is happening and happening as quickly as it is. Two weeks ago, we were in the backyard playing, she was running around like a little maniac and eating very well. Begging for her treats, etc... Now, two weeks later, she dying in front of my eyes and I feel helpless. The blindness, overnight, has me very concerned - could the cancer have done this? Still absolutely no appetite, she does want to drink water - but I give her only small amounts.

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    OMG I find this to be the saddest story I think I have EVER heard!!! I hope she gets feeling better . If there is Anything you need don't hesitate to ask. If you are having troubles with bills we could set up something for little chelsea. I'm sorry little chelsea is in such a sad state.

    PLEASE DON"T HESITATE TO ASK!!
    Love Megs
    Shred the concrete as well as the mountains
    "Do you support giving a dog a better life?

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    Junior Member mhowd's Avatar
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    Thanks Pupskersandhutch - I do appreciate your concerns. It just helps to know that there is support for me out there. I would take out a second mortgage on my house if I knew it would help - she's everything to me and it just hurts to see this happening. It really feels as though someone put a knife in my heart - just so difficult. This has happened just so quickly - but the vet told me that lymphoma can be like that. I had a black lab who lived to be 16 1/2 years old and Chelsea is just 9, so I feel as though she's just too young. I really thought I would have 6+ years left with her.

    Thanks again for your thoughts and prayers and most of all, support. I think just knowing that there are other animal lovers out there who understand, is probably the biggest help right now.

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    I have a little pup that's a Lab so I'm serious I will try to comfort you through the whole thing . Were all here sharing the exact same thing we love soo PLEASE I WOULD LIKE TO HELP please PM me I live in utah and I don't mind helping you out !!! good luck hopefully the blindness will subdue and everything will be okay stay strong!!!


    Love Megs
    Shred the concrete as well as the mountains
    "Do you support giving a dog a better life?

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    Junior Member mhowd's Avatar
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    Thanks - I sent a PM to you. It's moral support that I'm really in need of right now. Thanks to everyone and all the kind words and support. Not to sound pessimistic, but I have a feeling the cancer has just spread like wildfire throughout her system. I know I keep saying, but I just can't believe that in just two weeks time she has gone from a fun loving companion to so sick it hurts me so much.

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    All of this, just doesn't sound good and I'm afraid I will be faced with a very difficult decision tomorrow.
    Unfortunately, I agree, this doesn't sound good. I don't know what could cause the sudden blindness unless she is bleeding into her eyes. The liver controls clotting factors and they can have blood clotting problems if they have liver failure, and sometimes start bleeding in strange places.

    I think the ultrasound will probably tell you what is really going on tomorrow. If there are multiple masses in multiple organs, then there really isn't anything to do.

    I hope your decisions regarding what to do next are made clear for you tomorrow.

    I am so sorry she and you are going through this.

    Good luck. Take care.

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    Junior Member mhowd's Avatar
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    I took Chelsea for the Ultrasound and the news wasn't good. They are now (this afternoon) going to biopsy one or two of her lymph nodes to detect the stage of cancer and that may help me to determine any course of treatment that might be right for her. I should have the results of the biopsy in 2-3 days.

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    What did they see on the ultrasound?

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