I'm not sure what is best, but I've kept the crate in the same place-the computer room off of the kitchen.
She is 6 months now and we brought her home at 11 weeks. There were only a couple of nights when she cried during the night, and I heard her from upstairs.
We used a night-light for her and kept the radio on for the first few weeks. I don't know if it helped her, but I felt better thinking that she wasn't in the dark and that the music soothed her.
I'm just lazy and didn't want to lug the crate up and down. It worked fine for us....good luck!